Professional
Technical
In the Industry Vocabulary Test
pathological complete response
Absence of invasive cancer in breast and lymph nodes after neoadjuvant treatment.
Full Definition
Pathological complete response (pCR) refers to the absence of invasive carcinoma in both the breast and axillary lymph nodes following neoadjuvant therapy, as determined by microscopic examination of surgical specimens. The definition may vary slightly between studies, with some including or excluding ductal carcinoma in situ. Achieving pCR is considered a favorable prognostic indicator and is associated with improved long-term outcomes, particularly in triple-negative and HER2-positive breast cancers. pCR rates vary by breast cancer subtype and treatment regimen used.
Usage
Usage note: pCR is acceptable abbreviation in clinical contexts.
In Context
- "The patient achieved pathological complete response after neoadjuvant chemotherapy." — Pathology report
- "pCR rates are highest in triple-negative breast cancer." — Clinical trial publication
Also known as
pCR
complete pathological response
Contrasted with
residual disease
partial response
Don't confuse with
clinical complete response
partial pathological response