pCR
Also written as: pCR — pathological complete response
Abbreviation for pathological complete response, indicating no residual cancer after treatment.
Full Definition
pCR stands for pathological complete response, defined as the absence of residual invasive cancer in the breast and lymph nodes following neoadjuvant therapy. This endpoint is determined by microscopic examination of surgical specimens after preoperative systemic treatment. Achievement of pCR is associated with improved long-term outcomes, particularly in aggressive breast cancer subtypes like triple-negative and HER2-positive tumors. The definition may vary between studies regarding the inclusion of residual ductal carcinoma in situ.
Usage
Usage note: Use lowercase 'p' to distinguish from PCR (polymerase chain reaction).
In Context
- "Neoadjuvant chemotherapy achieved pCR in 45% of triple-negative cases." — clinical trial results
- "The surgical specimen confirmed pCR with no viable tumor cells identified." — pathology report