phyllodes tumor
Pronunciation: FY-loh-deez
A rare fibroepithelial breast tumor with leaf-like microscopic architecture, classified as benign, borderline, or malignant based on histological features.
Full Definition
Phyllodes tumors are uncommon fibroepithelial neoplasms of the breast, accounting for less than 1% of all breast tumors. These tumors are characterized by their distinctive leaf-like (phylloid) microscopic pattern, consisting of epithelial and stromal components. They are classified into three categories based on histological criteria: benign, borderline, and malignant. The classification depends on factors such as stromal cellularity, mitotic activity, stromal overgrowth, and the nature of tumor margins. Even benign phyllodes tumors can grow rapidly and reach considerable size. Treatment typically involves surgical excision with clear margins, and malignant variants may require wider excision. Local recurrence can occur, particularly with incomplete excision, and malignant phyllodes tumors have potential for distant metastasis.
Usage
Usage note: The term 'cystosarcoma phyllodes' is outdated and should not be used, as it incorrectly implies all phyllodes tumors are malignant.
In Context
- "Histopathology confirmed a benign phyllodes tumor with clear surgical margins." — Surgical pathology report
- "The rapidly growing breast mass was diagnosed as a borderline phyllodes tumor." — Clinical case presentation