peau d'orange
Pronunciation: poh-doh-RAHNZH
A clinical sign characterized by skin dimpling resembling an orange peel, typically associated with inflammatory breast cancer or advanced local disease.
Full Definition
Peau d'orange is a distinctive clinical finding where the skin of the breast develops a dimpled, orange peel-like appearance due to lymphatic obstruction and subsequent edema. This sign results from tumor cells blocking lymphatic drainage, causing fluid accumulation in the skin and prominent visualization of hair follicles and pores. Peau d'orange is most commonly associated with inflammatory breast cancer but can also occur in advanced cases of other breast cancer types with extensive lymphatic involvement. The finding is considered a poor prognostic sign and typically indicates locally advanced disease. Recognition of this clinical sign is crucial for prompt diagnosis and staging, as it may upstage the cancer and significantly alter treatment planning.
Usage
Usage note: French term meaning 'orange skin'; should be italicized in formal medical writing and pronunciation guide may be helpful for non-French speakers.
In Context
- "Physical examination revealed peau d'orange changes over the left breast." — Clinical examination note
- "The presence of peau d'orange prompted immediate biopsy and staging workup." — Urgent referral letter