heterotopic ossification
Pronunciation: HET-er-oh-TOP-ik os-ih-fih-KAY-shun
Abnormal bone formation in soft tissues that can occur after severe burn injuries.
Full Definition
Heterotopic ossification is the pathological formation of bone and cartilage in soft tissues where these structures do not normally occur, representing a rare but significant complication of severe burn injuries. In burn patients, this condition typically develops in areas of deep burns, particularly around joints, and can result in significant functional impairment and contractures. The pathogenesis involves the inappropriate activation of osteogenic pathways in mesenchymal cells, often triggered by the inflammatory response to severe thermal injury. Early recognition and treatment are important to prevent permanent joint dysfunction and maintain mobility.
Usage
Usage note: Often abbreviated as HO in clinical documentation.
In Context
- "Radiographic imaging revealed heterotopic ossification around the elbow joint." — Radiology report
- "Physical therapy was modified due to concerns about heterotopic ossification." — Rehabilitation consultation