integra
Pronunciation: in-TEG-rah
Bilayer skin substitute consisting of collagen matrix with silicone outer layer, used for temporary coverage and dermal regeneration.
Full Definition
Integra is a bilayer artificial skin substitute composed of a bovine collagen-glycosaminoglycan matrix with a temporary silicone outer layer. The collagen matrix serves as a scaffold for dermal regeneration and neovascularization, while the silicone layer provides barrier function. After integration (typically 2-3 weeks), the silicone layer is removed and replaced with thin autografts. Integra is particularly useful for large burns with limited donor sites or areas requiring improved functional and cosmetic outcomes.
Usage
Usage note: Integra is a trademarked product name and should be capitalized; the process is called 'Integra take' when successful integration occurs.
In Context
- "Integra was applied to the full-thickness hand burns with plans for autograft overlay in three weeks." — Operative report
- "The patient's Integra showed excellent vascularization at two weeks, ready for silicone layer removal." — Progress note