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cancer stem cell
Subpopulation of cancer cells with self-renewal capacity and tumor-initiating properties.
Full Definition
Cancer stem cells (CSCs) are a small subpopulation of cancer cells within tumors that possess stem cell-like properties including self-renewal capacity, pluripotency, and the ability to initiate tumor formation. These cells are thought to drive tumor growth, metastasis, and recurrence after treatment. CSCs are typically more resistant to conventional therapies including chemotherapy and radiation, potentially explaining treatment failures and disease relapse. They can be identified through specific cell surface markers, functional assays, or metabolic characteristics.
Usage
Usage note: Commonly abbreviated as CSC; concept remains somewhat controversial.
In Context
- "Cancer stem cell markers were enriched in the chemotherapy-resistant population." — Research manuscript
- "Targeting cancer stem cell pathways improved treatment outcomes." — Clinical trial report
Also known as
CSC
tumor-initiating cell
tumor stem cell
Contrasted with
differentiated cancer cell
Don't confuse with
stem cell
progenitor cell