cytokine release syndrome
Also written as: CRS — cytokine release syndrome
A potentially life-threatening immune response characterized by excessive release of inflammatory proteins.
Full Definition
Cytokine release syndrome (CRS) is a severe systemic inflammatory response that can occur as a side effect of certain cancer immunotherapies, particularly CAR-T cell therapy and some monoclonal antibodies. It results from the rapid and excessive release of inflammatory cytokines by activated immune cells, leading to symptoms ranging from fever and fatigue to life-threatening complications such as hypotension, respiratory distress, and organ dysfunction. CRS is graded on a severity scale and can be managed with supportive care and immunosuppressive agents like tocilizumab or corticosteroids. Early recognition and prompt treatment are crucial for patient safety.
Usage
Usage note: Can be abbreviated as CRS. Often confused with ICANS (neurotoxicity syndrome).
In Context
- "The patient developed grade 3 cytokine release syndrome requiring ICU admission." — Adverse event report
- "Tocilizumab was administered to manage severe CRS symptoms." — Treatment protocol