Intermediate
Technical
IVT
durable response
A sustained tumor response to treatment that persists for an extended period beyond typical expectations.
Full Definition
A durable response refers to a tumor response that is maintained for a prolonged period, typically defined as lasting at least 6-12 months or longer depending on the cancer type and treatment context. This concept is particularly important in immunotherapy where some patients experience long-lasting responses even after treatment discontinuation. Durable responses are associated with improved quality of life and overall survival, making them a key endpoint in evaluating new cancer therapies, especially in advanced disease settings.
Usage
Usage note: Specify duration criteria when possible; avoid confusion with complete response.
In Context
- "Fifteen percent of patients treated with the checkpoint inhibitor achieved durable responses lasting more than two years." — Clinical trial results
- "The patient maintained a durable response for 18 months before showing signs of disease progression." — Follow-up clinical note
Also known as
sustained response
long-lasting response
Contrasted with
transient response
short-lived response
Don't confuse with
complete response
stable disease
prolonged response