multidrug resistance
Cancer cell resistance to multiple chemotherapy agents simultaneously.
Full Definition
Multidrug resistance (MDR) is a phenomenon where cancer cells develop simultaneous resistance to multiple chemotherapy drugs with different mechanisms of action. This can occur through various mechanisms including overexpression of drug efflux pumps (particularly P-glycoprotein), altered drug metabolism, enhanced DNA repair capacity, or resistance to apoptosis. MDR represents a major obstacle in cancer treatment and can be either intrinsic (present before treatment) or acquired (developed during therapy). Understanding MDR mechanisms is crucial for developing strategies to overcome treatment resistance.
Usage
Usage note: Commonly abbreviated as MDR; specify mechanism when known.
In Context
- "The tumor demonstrated multidrug resistance to standard chemotherapy regimens." — Clinical case report
- "P-glycoprotein overexpression mediated multidrug resistance in these cell lines." — Research manuscript