comprehensive genomic profiling
Simultaneous analysis of multiple classes of genomic alterations across hundreds of cancer-related genes using next-generation sequencing.
Full Definition
Comprehensive genomic profiling (CGP) is an advanced molecular diagnostic approach that simultaneously examines multiple types of genomic alterations including point mutations, insertions/deletions, copy number variations, and structural rearrangements across a broad panel of cancer-relevant genes. CGP typically analyzes 300-500 genes or more, providing a comprehensive view of a tumor's genetic landscape in a single assay. This approach maximizes the likelihood of identifying actionable mutations, biomarkers for immunotherapy response, and genomic signatures relevant to prognosis and treatment selection. CGP has become increasingly important in precision oncology for guiding personalized treatment decisions.
Usage
Usage note: Abbreviate as CGP after first use; distinguish from more limited gene panel testing.
In Context
- "Comprehensive genomic profiling identified three actionable mutations suitable for targeted therapy." — Molecular tumor board discussion
- "The comprehensive genomic profiling report included microsatellite instability and tumor mutational burden assessments." — Clinical laboratory report