concordance analysis
Statistical comparison of genomic test results between different platforms, time points, or sample types to assess reliability.
Full Definition
Concordance analysis is a statistical evaluation method used in cancer genomics to assess the agreement between genomic test results obtained from different analytical platforms, testing methodologies, sample types, or time points. This analysis is crucial for validating new testing technologies, comparing results between laboratories, evaluating the consistency of serial testing over time, and assessing the reliability of different sample types such as tissue versus liquid biopsies. Concordance metrics typically include overall percent agreement, positive percent agreement, negative percent agreement, and statistical measures such as Cohen's kappa or concordance correlation coefficients. In clinical practice, concordance analysis helps establish confidence intervals for genomic test results and guides decisions about when repeat testing or alternative approaches may be necessary.
Usage
Usage note: Results often expressed as percentage agreement with confidence intervals.
In Context
- "Concordance analysis between tissue and plasma testing showed 89% agreement for actionable mutations." — Clinical validation study
- "The laboratory performed concordance analysis to validate their new sequencing platform." — Quality assurance report