NGS
Also written as: NGS — next-generation sequencing
Next-generation sequencing technologies that enable rapid, high-throughput analysis of DNA and RNA sequences.
Full Definition
Next-generation sequencing (NGS) encompasses a family of advanced sequencing technologies that can simultaneously sequence millions of DNA or RNA fragments. In cancer genomics, NGS has revolutionized the ability to comprehensively analyze tumor genomes, transcriptomes, and epigenomes at unprecedented scale and resolution. NGS platforms enable the detection of various genomic alterations including point mutations, insertions, deletions, copy number variations, and structural rearrangements. The technology supports both targeted gene panels and whole genome/exome sequencing approaches for cancer diagnosis, prognosis, and treatment selection.
Usage
Usage note: Spell out on first use, then use NGS; avoid confusion with other sequencing acronyms.
In Context
- "The oncology team ordered NGS testing to identify potential therapeutic targets." — Clinical order
- "NGS analysis revealed multiple copy number alterations across the tumor genome." — Laboratory report