panel sequencing
Targeted next-generation sequencing of a predefined set of cancer-related genes using capture-based enrichment.
Full Definition
A focused genomic sequencing approach that simultaneously analyzes multiple genes associated with cancer using hybridization-based target capture methods. Panel sequencing typically covers hundreds of cancer-relevant genes, providing broader coverage than amplicon-based methods while being more cost-effective than whole exome sequencing. Clinical cancer gene panels are designed to detect actionable mutations, copy number variations, and structural variants across oncogenes and tumor suppressor genes relevant to treatment selection.
Usage
Usage note: Specify the number of genes when editing clinical documents; distinguish from single-gene or amplicon-based approaches.
In Context
- "The 500-gene panel sequencing revealed multiple actionable alterations in the breast cancer specimen." — Genomic testing report
- "Panel sequencing provides comprehensive mutation profiling while maintaining clinical turnaround times." — Laboratory method description