OncoKB
Pronunciation: ON-ko-K-B
A precision oncology knowledge base that annotates the biological and clinical relevance of cancer variants.
Full Definition
OncoKB is a comprehensive knowledge base developed by Memorial Sloan Kettering Cancer Center that provides evidence-based annotations for cancer variants. It categorizes variants into levels of evidence (Level 1-4 and R1-R3) based on their clinical actionability and therapeutic implications. The platform helps clinicians and researchers interpret the significance of genomic alterations in cancer patients. Editors must understand OncoKB's tiered evidence system when reviewing precision oncology reports and ensure consistent formatting of OncoKB level annotations throughout documents.
Usage
Usage note: Use consistent capitalization (OncoKB, not oncoKB). Always specify evidence level when citing OncoKB annotations.
In Context
- "The EGFR L858R mutation was classified as OncoKB Level 1 evidence for erlotinib therapy in lung adenocarcinoma." — precision oncology report
- "According to OncoKB annotations, this variant has Level 4 evidence for potential therapeutic targeting." — molecular tumor board summary