atypical glandular cells
Also written as: AGC — Atypical Glandular Cells
Abnormal cervical cytology finding indicating cells from the cervical canal or endometrium that appear atypical but not definitively malignant.
Full Definition
Atypical glandular cells represent a category of abnormal cervical cytology results under the Bethesda System, indicating cellular changes that exceed normal variation but fall short of a definitive cancer diagnosis. AGC findings require immediate colposcopic evaluation and often endometrial assessment, as they may indicate precancerous or cancerous conditions of the cervix, endometrium, or other gynecologic organs. The finding is less common than squamous cell abnormalities but carries higher risk for underlying significant pathology, necessitating prompt and thorough evaluation.
Usage
Usage note: Always specify whether AGC is favor neoplastic or not otherwise specified (NOS) when available.
In Context
- "The cytology report showed atypical glandular cells, prompting immediate referral for colposcopy and endometrial evaluation." — Referral letter
- "Quality assurance protocols require review of all AGC diagnoses by senior cytotechnologists." — Laboratory policy document