high-grade squamous intraepithelial lesion
Also written as: HSIL — High-grade Squamous Intraepithelial Lesion
Bethesda System category indicating moderate to severe cervical dysplasia with significant potential for progression to invasive cancer.
Full Definition
High-grade squamous intraepithelial lesion represents a cytologic diagnosis under the Bethesda System encompassing moderate dysplasia (CIN 2), severe dysplasia (CIN 3), and carcinoma in situ. HSIL indicates significant cellular abnormalities with substantial risk of progression to invasive cervical cancer if untreated. This diagnosis requires immediate colposcopic evaluation and typically necessitates treatment through procedures such as LEEP, cold knife conization, or cryotherapy. HSIL findings are strongly associated with high-risk HPV infections and require close follow-up even after treatment.
Usage
Usage note: Distinguish clearly from LSIL; HSIL always requires immediate intervention.
In Context
- "The cytology result of HSIL requires urgent colposcopy referral within four weeks of notification." — Clinical protocol
- "Quality metrics include tracking time from HSIL diagnosis to completed treatment." — Quality assurance report