tranexamic acid
Pronunciation: tran-ex-AM-ic
Antifibrinolytic medication that reduces bleeding by inhibiting plasmin activation and clot breakdown.
Full Definition
Tranexamic acid is a synthetic lysine analogue that prevents fibrinolysis by blocking the conversion of plasminogen to plasmin, thereby stabilizing formed clots and reducing bleeding. In cardiac surgery, it is routinely administered to minimize perioperative blood loss and transfusion requirements, typically given as a loading dose followed by continuous infusion throughout the procedure. The drug has largely replaced aprotinin due to its superior safety profile, with minimal risks of allergic reactions or organ toxicity while maintaining effective antifibrinolytic properties.
Usage
Usage note: Specify dosing protocol clearly; TXA abbreviation acceptable in clinical documentation.
In Context
- "Tranexamic acid was administered as 10 mg/kg loading dose followed by 1 mg/kg/hr infusion." — Anesthesia medication record
- "Routine tranexamic acid use reduced blood transfusion rates by 35% in our cardiac surgery program." — Quality improvement analysis