coronary flow reserve
Also written as: CFR — coronary flow reserve
The ratio of maximal coronary blood flow during hyperemia to resting coronary blood flow, indicating coronary vascular function.
Full Definition
Coronary flow reserve (CFR) represents the capacity of the coronary circulation to increase blood flow in response to maximal vasodilation, typically achieved through adenosine administration. It is calculated as the ratio of peak hyperemic flow to baseline resting flow and reflects the functional status of both epicardial coronary arteries and coronary microcirculation. Normal CFR values are typically ≥2.0, while reduced values may indicate epicardial stenosis, microvascular dysfunction, or both. CFR can be measured using various techniques including Doppler echocardiography, cardiac MRI, or PET imaging, and provides valuable information about overall coronary vascular health beyond what anatomical imaging alone can provide.
Usage
Usage note: CFR is acceptable abbreviation after first use; avoid confusing with FFR.
In Context
- "The reduced coronary flow reserve of 1.6 suggests significant microvascular impairment." — PET perfusion study report
- "Despite normal epicardial arteries, the patient's CFR was markedly diminished, indicating microvascular disease." — Cardiac catheterization report