coronary flow reserve
Also written as: CFR — Coronary Flow Reserve
Measure of maximum achievable coronary blood flow relative to resting flow under pharmacologic stress.
Full Definition
Coronary flow reserve (CFR) is a functional assessment that measures the ratio of maximum achievable coronary blood flow during pharmacologic vasodilation to resting coronary blood flow. CFR reflects the integrated function of both epicardial coronary arteries and coronary microcirculation. Normal CFR values are typically greater than 2.0, while reduced values suggest either epicardial stenosis or microvascular dysfunction. CFR can be measured invasively using Doppler flow wires during cardiac catheterization or non-invasively using echocardiography, PET, or cardiac MRI. This measurement helps assess the functional significance of coronary lesions and guide treatment decisions.
Usage
Usage note: May be abbreviated as CFR; distinguish clearly from FFR measurements.
In Context
- "Coronary flow reserve measurement revealed significant microvascular impairment." — Physiology study report
- "The reduced coronary flow reserve of 1.8 suggested hemodynamically significant stenosis." — Invasive assessment