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no-reflow
A phenomenon characterized by impaired myocardial perfusion despite successful epicardial vessel opening during PCI.
Full Definition
No-reflow refers to the absence of adequate myocardial tissue perfusion despite successful restoration of epicardial coronary flow during percutaneous coronary intervention. This phenomenon is characterized by impaired microvascular circulation, often due to distal embolization, microvascular spasm, or endothelial dysfunction. No-reflow is associated with larger infarct size, reduced left ventricular function, and worse clinical outcomes. Treatment may include vasodilators, antiplatelet agents, or mechanical protection devices.
Usage
Usage note: Always hyphenate when used as a compound modifier.
In Context
- "Despite successful stent deployment, the patient developed no-reflow requiring adenosine administration." — STEMI intervention report
- "No-reflow phenomenon was evident on angiography with poor myocardial blush grade." — Procedural complication documentation
Also known as
microvascular dysfunction
impaired myocardial perfusion
Contrasted with
normal perfusion
TIMI 3 flow
Don't confuse with
slow flow
distal embolization