no-reflow phenomenon
Inadequate myocardial perfusion despite successful recanalization of an epicardial coronary artery during PCI.
Full Definition
The no-reflow phenomenon refers to the absence of adequate myocardial perfusion following successful mechanical restoration of epicardial coronary flow during PCI. This complication occurs due to microvascular obstruction caused by distal embolization of thrombotic or atherosclerotic debris, vasospasm, or ischemia-reperfusion injury. No-reflow is associated with larger infarct size, reduced left ventricular function, and worse clinical outcomes. Treatment strategies include aspiration thrombectomy, distal protection devices, and vasodilator medications.
Usage
Usage note: Hyphenate 'no-reflow' when used as compound modifier; may appear without hyphen in some literature.
In Context
- "Despite successful stent deployment, the patient developed no-reflow phenomenon requiring intracoronary vasodilator therapy." — Case report
- "The no-reflow phenomenon complicated 5% of primary PCI procedures in the registry." — Clinical database analysis