MACE
Also written as: MACE — major adverse cardiac events
Major adverse cardiac events, a composite endpoint used in cardiovascular clinical trials and outcomes research.
Full Definition
MACE represents a standardized composite endpoint that typically includes cardiovascular death, myocardial infarction, and stroke, though definitions may vary between studies to include revascularization procedures, hospitalization for heart failure, or other cardiovascular events. This endpoint was developed to provide adequate statistical power in clinical trials by combining related but distinct cardiovascular outcomes. MACE rates are commonly reported at 30 days, one year, and longer follow-up periods in both clinical trials and registry studies. The specific components of MACE should always be clearly defined when reporting outcomes, as variations in definition can significantly impact study results and interpretation. MACE serves as a crucial measure of cardiovascular risk and treatment efficacy.
Usage
Usage note: Always specify the exact components included in MACE definition when reporting outcomes.
In Context
- "The primary endpoint was MACE at one year, defined as cardiovascular death, myocardial infarction, or stroke." — Clinical trial protocol
- "Patients in the intervention group had a 25% reduction in MACE compared to standard therapy." — Research publication