ASCOT-LLA
Also written as: ASCOT-LLA — Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm
Landmark clinical trial that demonstrated cardiovascular benefits of statin therapy in patients with hypertension.
Full Definition
The Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm was a major randomized controlled trial that evaluated atorvastatin versus placebo in hypertensive patients without prior coronary heart disease. The trial was terminated early due to significant reduction in cardiovascular events with statin therapy. ASCOT-LLA provided crucial evidence for the cardiovascular benefits of statins beyond cholesterol lowering in primary prevention settings. The trial's findings significantly influenced guidelines for statin use in patients with multiple cardiovascular risk factors. Results from ASCOT-LLA are frequently cited in cardiometabolic literature when discussing primary prevention strategies.
Usage
Usage note: Always spell out on first use; commonly referenced in primary prevention discussions
In Context
- "The ASCOT-LLA trial demonstrated that atorvastatin reduced cardiovascular events by 36% in hypertensive patients." — Clinical research paper
- "Guidelines now recommend statin therapy based partly on evidence from ASCOT-LLA." — Treatment guideline document