atherogenic dyslipidemia
A lipid pattern characterized by elevated triglycerides, low HDL cholesterol, and predominance of small dense LDL particles, commonly associated with insulin resistance.
Full Definition
Atherogenic dyslipidemia is a specific pattern of lipid abnormalities that significantly increases cardiovascular risk, particularly prevalent in patients with insulin resistance, metabolic syndrome, and type 2 diabetes. The classic triad consists of elevated triglycerides, reduced HDL cholesterol, and a shift toward small, dense LDL particles that are more atherogenic than large, buoyant LDL particles. This lipid phenotype is often present even when total and LDL cholesterol levels appear normal, making it a particularly insidious cardiovascular risk factor. The pattern results from increased hepatic VLDL production and altered lipoprotein metabolism associated with insulin resistance. Treatment typically involves lifestyle modifications, statin therapy, and sometimes fibrates or other triglyceride-lowering agents.
Usage
Usage note: Hyphenate when used as an adjective. Emphasizes the pro-atherogenic nature of this lipid pattern.
In Context
- "The patient exhibited classic atherogenic dyslipidemia with a triglyceride level of 300 mg/dL and HDL of 32 mg/dL." — Cardiology consultation note
- "Atherogenic dyslipidemia is often underrecognized as a cardiovascular risk factor in diabetes care." — Diabetes management review