coronary flow reserve
Ratio of maximal coronary blood flow during vasodilation to resting coronary flow, measuring coronary microvascular function.
Full Definition
Coronary flow reserve (CFR) represents the capacity of the coronary circulation to increase blood flow in response to maximal vasodilation, typically measured as the ratio of peak hyperemic flow to resting flow. CFR reflects the functional status of both epicardial coronary arteries and coronary microcirculation, with normal values typically greater than 2.5-3.0. Reduced CFR can result from epicardial stenosis, microvascular dysfunction, or both, making it a valuable parameter for assessing overall coronary circulatory function. In cardiometabolic medicine, impaired CFR is often observed in diabetes and metabolic syndrome, even without significant epicardial coronary disease. CFR measurement has become an important tool for risk stratification and treatment monitoring in patients with cardiometabolic disorders.
Usage
Usage note: Distinguish from fractional flow reserve (FFR); specify measurement technique when relevant
In Context
- "Diabetic patients showed reduced coronary flow reserve despite normal angiograms." — Cardiac imaging study
- "PET imaging revealed impaired coronary flow reserve in the metabolic syndrome group." — Research manuscript