HFPEF
Also written as: HFPEF — Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction, increasingly recognized in patients with metabolic disorders. Characterized by diastolic dysfunction despite normal systolic function.
Full Definition
Heart failure with preserved ejection fraction (HFPEF) is a clinical syndrome where patients experience heart failure symptoms despite maintaining normal or near-normal left ventricular ejection fraction (typically ≥50%). This condition is strongly associated with cardiometabolic risk factors including diabetes, obesity, and hypertension. HFPEF primarily involves diastolic dysfunction, where the heart muscle becomes stiff and unable to relax properly during filling. The prevalence of HFPEF is increasing, particularly among elderly patients with multiple cardiometabolic comorbidities, and it represents a significant challenge as therapeutic options remain limited compared to HFREF.
Usage
Usage note: Avoid the older term 'diastolic heart failure' which is less precise.
In Context
- "The patient's HFPEF was likely secondary to longstanding diabetes and hypertension." — Clinical assessment
- "HFPEF management focuses on controlling comorbid cardiometabolic conditions." — Treatment plan