HFREF
Also written as: HFREF — Heart Failure with Reduced Ejection Fraction
Heart failure with reduced ejection fraction, a specific type of heart failure common in diabetic patients. Distinguished from heart failure with preserved ejection fraction (HFPEF).
Full Definition
Heart failure with reduced ejection fraction (HFREF) is a clinical syndrome characterized by impaired left ventricular systolic function, typically defined as an ejection fraction of 40% or less. This condition is particularly prevalent in patients with diabetes and metabolic syndrome due to the cardiotoxic effects of chronic hyperglycemia and insulin resistance. HFREF represents a distinct phenotype from heart failure with preserved ejection fraction (HFPEF), requiring different therapeutic approaches. Patients with cardiometabolic conditions face higher risks of developing HFREF due to accelerated coronary artery disease and diabetic cardiomyopathy.
Usage
Usage note: Distinguish clearly from HFPEF and HFmrEF (heart failure with mildly reduced ejection fraction).
In Context
- "The echocardiogram revealed HFREF with an ejection fraction of 25% in this diabetic patient." — Cardiology consultation
- "ACE inhibitors remain first-line therapy for HFREF in patients with cardiometabolic disease." — Treatment guideline