lipoprotein(a)
Pronunciation: LIE-poh-PRO-teen-ay
Atherogenic lipoprotein particle strongly associated with cardiovascular disease risk.
Full Definition
Lipoprotein(a) [Lp(a)] is a cholesterol-rich lipoprotein particle consisting of an LDL-like particle covalently linked to apolipoprotein(a). Plasma levels are primarily determined by genetic factors and remain relatively stable throughout life. Elevated Lp(a) levels, typically above 50 mg/dL or 125 nmol/L, are associated with increased risk of atherosclerotic cardiovascular disease, aortic stenosis, and venous thromboembolism. Unlike other lipoproteins, Lp(a) levels respond minimally to conventional lipid-lowering therapies, requiring specialized treatments for significant reduction.
Usage
Usage note: Include parentheses around 'a' in full term; may abbreviate as Lp(a).
In Context
- "Elevated lipoprotein(a) levels above 50 mg/dL confer additional cardiovascular risk beyond LDL cholesterol." — Risk assessment guideline
- "Family history of premature CAD warrants lipoprotein(a) measurement for risk stratification." — Clinical recommendation