NASH
Also written as: NASH — Non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis, an advanced form of fatty liver disease with inflammation.
Full Definition
Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease characterized by hepatic steatosis, inflammation, and hepatocyte injury in the absence of significant alcohol consumption. NASH represents the more severe end of the NAFLD spectrum and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. The condition is strongly associated with metabolic syndrome, diabetes, and obesity, sharing common pathophysiological mechanisms including insulin resistance and chronic inflammation. Diagnosis typically requires liver biopsy, though non-invasive biomarkers and imaging techniques are increasingly utilized.
Usage
Usage note: Always capitalize NASH; distinguish from NAFLD in clinical documentation.
In Context
- "Liver biopsy confirmed the diagnosis of NASH with stage 2 fibrosis in this diabetic patient." — Pathology report
- "Weight loss of 7-10% can lead to NASH resolution in a significant proportion of patients." — Treatment guideline