milrinone

Full Definition

Milrinone is a phosphodiesterase-3 inhibitor used as an inotropic agent in cardiac anesthesia and critical care. It increases cardiac contractility by elevating intracellular cyclic adenosine monophosphate levels while simultaneously causing peripheral and pulmonary vasodilation. This dual mechanism makes milrinone particularly valuable in patients with heart failure and elevated pulmonary vascular resistance, though it may cause hypotension in volume-depleted patients.

Usage

Usage note: Specify dosing in mcg/kg/min; monitor for hypotension and arrhythmias

In Context

• "Milrinone infusion was initiated at 0.5 mcg/kg/min for post-bypass low cardiac output syndrome." — Medication order