aprotinin
Pronunciation: ah-PROE-ti-nin
Antifibrinolytic agent previously used to reduce bleeding in cardiac surgery, now largely discontinued due to safety concerns.
Full Definition
A serine protease inhibitor derived from bovine lung that was widely used in cardiac surgery to reduce perioperative bleeding by inhibiting plasmin and kallikrein. Aprotinin was particularly effective in reducing blood loss and transfusion requirements in complex cardiac procedures. However, its use was largely discontinued after studies suggested increased risks of renal failure, myocardial infarction, and stroke. Understanding its historical use and why it was discontinued is important for cardiovascular anesthesiologists.
Usage
Usage note: Historical importance; largely discontinued due to safety concerns. Brand name was Trasylol.
In Context
- "Prior to 2007, aprotinin was commonly used in redo cardiac surgeries to minimize bleeding complications." — Historical review
- "The patient's previous cardiac surgery records indicate aprotinin was administered, which may be relevant to current renal function." — Pre-operative assessment