Intermediate
Technical
IVT
epsilon-aminocaproic acid
Also written as: EACA
Antifibrinolytic medication used to reduce bleeding by inhibiting plasmin activation during cardiac surgery.
Full Definition
A synthetic lysine analog that acts as an antifibrinolytic agent by competitively inhibiting the activation of plasminogen to plasmin, thereby reducing fibrinolysis and bleeding. Commonly used in cardiac surgery to decrease perioperative blood loss and transfusion requirements. It is administered as a loading dose followed by continuous infusion throughout the procedure. Side effects may include hypotension, bradycardia, and rare thrombotic complications.
Usage
Usage note: Brand name Amicar; commonly abbreviated as EACA or aminocaproic acid in clinical practice.
In Context
- "Epsilon-aminocaproic acid infusion was initiated at 10 mg/kg/hr after the loading dose." — Anesthesia record
- "The patient received epsilon-aminocaproic acid prophylactically to minimize bleeding risk in this redo sternotomy." — Operative note
Also known as
aminocaproic acid
EACA
Amicar
Don't confuse with
tranexamic acid
aprotinin