Professional
Technical
In the Industry Vocabulary Test
heparinization
Pronunciation: HEP-ah-rin-ih-ZAY-shun
Process of administering heparin to achieve therapeutic anticoagulation, typically before cardiopulmonary bypass.
Full Definition
Heparinization is the systematic administration of heparin to achieve and maintain therapeutic anticoagulation during cardiovascular procedures. The process involves initial bolus dosing (typically 300-400 units/kg), monitoring with activated clotting time (ACT), and additional dosing to maintain ACT above 450-480 seconds during cardiopulmonary bypass. Adequate heparinization is critical to prevent thrombosis in the bypass circuit and embolic complications.
Usage
Usage note: Document ACT values and timing of heparin administration for quality assurance.
In Context
- "Full heparinization was achieved with an ACT of 520 seconds before bypass initiation." — Coagulation monitoring log
- "Additional heparin was required during the procedure to maintain adequate heparinization." — Anesthesia record
Also known as
anticoagulation
heparin therapy
Contrasted with
protamine reversal
decannulation
Don't confuse with
coagulation
hemostasis