fractional flow reserve
Invasive measurement of coronary artery pressure to assess functional significance of stenoses.
Full Definition
Fractional flow reserve is an invasive hemodynamic technique that measures the pressure gradient across a coronary stenosis during maximal hyperemia to determine its functional significance. FFR is calculated as the ratio of distal coronary pressure to aortic pressure under pharmacologic stress, typically with adenosine. Values below 0.80 indicate hemodynamically significant stenosis requiring intervention. FFR-guided revascularization has been shown to improve outcomes compared to angiography-guided decisions alone. This technique helps avoid unnecessary procedures for angiographically apparent but functionally insignificant lesions.
Usage
Usage note: Commonly abbreviated as FFR; values are expressed as decimals, not percentages.
In Context
- "Fractional flow reserve measurement of the mid-LAD lesion was 0.75, indicating hemodynamic significance." — Cardiac catheterization report
- "The 60% stenosis had an FFR of 0.85, suggesting medical management would be appropriate." — Interventional cardiology consultation