GLS
Also written as: GLS — Global Longitudinal Strain
Global Longitudinal Strain, a measure of overall left ventricular function representing the average longitudinal deformation of all myocardial segments.
Full Definition
Global Longitudinal Strain (GLS) is a quantitative parameter that measures the average longitudinal shortening of the left ventricular myocardium during systole. Expressed as a negative percentage, normal GLS values typically range from -18% to -24%. GLS is considered more sensitive than ejection fraction for detecting early myocardial dysfunction and has strong prognostic value in various cardiac conditions. This parameter is particularly useful for detecting subclinical dysfunction in patients receiving cardiotoxic chemotherapy, early heart failure, and subtle regional wall motion abnormalities.
Usage
Usage note: Always express as a negative value; more negative values indicate better function.
In Context
- "GLS was reduced at -14%, indicating subclinical left ventricular dysfunction despite normal ejection fraction." — Strain echocardiography report
- "Serial monitoring of GLS is recommended during cardiotoxic chemotherapy to detect early myocardial injury." — Cardio-oncology protocol