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Professional Technical IVT

perfusion-metabolism mismatch

PET imaging pattern showing reduced blood flow but preserved glucose metabolism, indicating viable hibernating myocardium.

Full Definition

Perfusion-metabolism mismatch is a specific pattern identified on cardiac PET imaging that indicates myocardial viability in regions with reduced contractile function. This pattern occurs when perfusion tracers (such as rubidium-82 or nitrogen-13 ammonia) show decreased uptake while metabolic tracers (typically fluorine-18 FDG) demonstrate preserved or enhanced glucose uptake. This mismatch pattern is the gold standard for identifying hibernating myocardium that is likely to recover function following successful revascularization, making it crucial for surgical decision-making in patients with ischemic cardiomyopathy.

Usage

Usage note: Specify the perfusion and metabolic tracers used, as protocols may vary between institutions.

In Context

  • "PET viability study demonstrated perfusion-metabolism mismatch in 60% of the anterior wall, supporting revascularization." — Cardiac PET report
  • "The absence of perfusion-metabolism mismatch suggests transmural scar rather than viable tissue." — Viability assessment interpretation

Also known as

viability pattern hibernation pattern

Contrasted with

matched defect scar pattern

Don't confuse with

perfusion-metabolism match partial thickness defect

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