Aschoff giant cell
Pronunciation: ASH-off JI-ant sel
Multinucleated giant cell characteristic of rheumatic carditis, containing fragmented nuclei arranged in a caterpillar or ribbon pattern.
Full Definition
Aschoff giant cells are pathognomonic multinucleated cells found in rheumatic heart disease, specifically within Aschoff nodules. These cells contain 5-15 nuclei arranged in a distinctive caterpillar or ribbon-like configuration with prominent nucleoli. They represent a fusion of activated macrophages and are considered a hallmark histologic feature for diagnosing acute rheumatic carditis. The presence of these cells, along with other inflammatory components, helps pathologists confirm rheumatic involvement of cardiac tissue.
Usage
Usage note: Always capitalize 'Aschoff' as it is an eponym. Distinguish from other types of giant cells in cardiac pathology.
In Context
- "The presence of Aschoff giant cells within the myocardial inflammatory infiltrate confirmed the diagnosis of acute rheumatic carditis." — Histopathology report
- "Multiple Aschoff giant cells with characteristic caterpillar nuclei were identified in the interstitial tissue." — Cardiac biopsy analysis