cardiac fibroma
Benign cardiac tumor composed of mature fibrous tissue, most commonly occurring in children and often associated with Gorlin syndrome.
Full Definition
Cardiac fibroma is the second most common primary cardiac tumor in children, consisting of mature fibrous connective tissue. These tumors are typically large, solitary, and occur most frequently in the ventricular septum or free wall. Histologically, fibromas are composed of mature fibroblasts and collagen fibers with minimal cellularity and no mitotic activity. They can be associated with Gorlin syndrome (nevoid basal cell carcinoma syndrome). Unlike myxomas, fibromas are firm, well-demarcated, and non-myxoid. Clinical presentation depends on size and location, ranging from asymptomatic to heart failure, arrhythmias, or sudden death due to conduction system involvement. Surgical resection may be necessary if the tumor causes significant symptoms or hemodynamic compromise.
Usage
Usage note: Second most common pediatric cardiac tumor; may be associated with Gorlin syndrome.
In Context
- "MRI revealed a large cardiac fibroma in the left ventricular free wall causing outflow obstruction." — Radiology report
- "Histological examination confirmed cardiac fibroma with mature fibrous tissue and no malignant features." — Surgical pathology report