endomyocardial fibrosis
A restrictive cardiomyopathy characterized by fibrotic thickening of the endocardium, predominantly affecting tropical regions.
Full Definition
Endomyocardial fibrosis is a restrictive heart disease characterized by fibrous thickening of the endocardium, particularly affecting the ventricular apices and inflow regions. The condition is most prevalent in tropical and subtropical regions and may be related to eosinophil-mediated damage. The fibrotic process can involve chordae tendineae and papillary muscles, leading to valvular dysfunction. Microscopically, there is dense collagenous tissue replacement of the normal endocardium and subendocardial myocardium.
Usage
Usage note: Should be distinguished from Löffler endocarditis, which has similar morphology but different etiology.
In Context
- "The gross findings were consistent with endomyocardial fibrosis affecting both ventricles." — Autopsy report
- "Microscopic examination confirmed endomyocardial fibrosis with dense collagenous replacement." — Pathology report