endomyocardial fibrosis with eosinophilia
Restrictive cardiomyopathy with endocardial fibrosis and tissue eosinophilia, often associated with hypereosinophilic syndrome.
Full Definition
Endomyocardial fibrosis with eosinophilia is a form of restrictive cardiomyopathy characterized by progressive fibrosis of the endocardium and subendocardium, accompanied by tissue and often peripheral eosinophilia. This condition is part of the spectrum of hypereosinophilic syndromes and may progress through acute necrotic, thrombotic, and chronic fibrotic stages. Histologically, the endocardium shows dense collagenous fibrosis with inflammatory infiltrates rich in eosinophils. The condition typically affects the inflow portions and apices of the ventricles, leading to restricted diastolic filling. Mural thrombi may form on the damaged endocardium, potentially causing systemic embolization.
Usage
Usage note: Specify 'with eosinophilia' to distinguish from tropical endomyocardial fibrosis, which lacks eosinophilic infiltrates.
In Context
- "Biopsy revealed endomyocardial fibrosis with eosinophilia, showing dense endocardial scarring and numerous tissue eosinophils." — Endomyocardial biopsy report
- "The patient's endomyocardial fibrosis with eosinophilia was associated with a peripheral eosinophil count of 15,000 cells/μL." — Clinicopathologic correlation