fibrinoid necrosis
Pathologic tissue death characterized by deposition of fibrin-like material in vessel walls, commonly seen in hypertensive cardiovascular disease.
Full Definition
Fibrinoid necrosis is a specific type of tissue necrosis characterized by the deposition of fibrin-like proteinaceous material in blood vessel walls, particularly affecting arterioles and small arteries. This pathologic process is commonly observed in malignant hypertension, acute arterial hypertension, and various vasculitic conditions. The term describes both the gross appearance of the affected tissue and the underlying pathophysiologic mechanism involving vessel wall damage and protein extravasation.
Usage
Usage note: Always hyphenate when used as a compound modifier; distinguish from other types of necrosis in pathologic descriptions.
In Context
- "Microscopic examination revealed extensive fibrinoid necrosis of the coronary arterioles consistent with malignant hypertensive changes." — Autopsy report
- "The presence of fibrinoid necrosis in the renal vessels supported the diagnosis of hypertensive nephrosclerosis." — Pathology consultation