floppy mitral valve syndrome
Mitral valve prolapse with myxomatous thickening and redundancy of valve leaflets, often leading to mitral regurgitation.
Full Definition
Floppy mitral valve syndrome, also known as mitral valve prolapse syndrome, is characterized by abnormal systolic displacement of mitral valve leaflets into the left atrium. The condition involves myxomatous degeneration with accumulation of glycosaminoglycans in the valve tissue, leading to leaflet thickening, elongation, and redundancy. Histologically, the valve shows disrupted collagen architecture and increased proteoglycan content. The syndrome can be primary (idiopathic) or secondary to connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome.
Usage
Usage note: Distinguish from simple mitral valve prolapse, which may lack the myxomatous changes.
In Context
- "Gross examination revealed floppy mitral valve syndrome with severe leaflet redundancy and chordal elongation." — Surgical pathology report
- "The patient's floppy mitral valve syndrome progressed to severe mitral regurgitation requiring surgical intervention." — Clinical correlation note