hypertrophic cardiomyopathy
Also written as: HCM — hypertrophic cardiomyopathy
Genetic cardiac disorder characterized by asymmetric left ventricular wall thickening in the absence of other causes.
Full Definition
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition featuring abnormal thickening of the heart muscle, particularly the left ventricle, without an identifiable external cause such as hypertension or valve disease. The condition is most commonly caused by mutations in genes encoding sarcomeric proteins. HCM can lead to outflow tract obstruction, arrhythmias, and sudden cardiac death, particularly in young athletes. Pathological examination reveals myofiber disarray, interstitial fibrosis, and abnormal intramyocardial coronary arteries.
Usage
Usage note: Often abbreviated as HCM in clinical contexts; distinguish from secondary hypertrophy due to hypertension.
In Context
- "The autopsy revealed hypertrophic cardiomyopathy with severe septal thickening and myofiber disarray." — Forensic pathology report
- "Genetic testing confirmed a pathogenic variant associated with hypertrophic cardiomyopathy." — Clinical genetics consultation