Libman-Sacks endocarditis
Pronunciation: LIB-man SAKS
Non-infectious endocarditis associated with systemic lupus erythematosus, characterized by small, warty vegetations.
Full Definition
Libman-Sacks endocarditis is a form of non-bacterial thrombotic endocarditis most commonly associated with systemic lupus erythematosus (SLE) and antiphospholipid syndrome. The condition is characterized by small, warty, non-destructive vegetations composed of fibrin, platelet aggregates, and inflammatory cells, typically affecting the mitral and aortic valves. Unlike infectious endocarditis, these vegetations are usually smaller, less destructive, and located on the ventricular surface of valves. The lesions can lead to valve dysfunction, systemic embolization, and increased risk of secondary bacterial infection. The condition was first described by Emanuel Libman and Benjamin Sacks in 1924.
Usage
Usage note: Eponymous term named after Libman and Sacks; specifically associated with lupus and APS.
In Context
- "The mitral valve showed characteristic Libman-Sacks endocarditis with small, warty vegetations." — Autopsy report
- "Echocardiography revealed valve thickening consistent with Libman-Sacks endocarditis in this SLE patient." — Cardiology consultation