Löffler endocarditis
Pronunciation: LEFF-ler
Eosinophil-mediated endocardial disease with thrombosis and fibrosis, representing the cardiac manifestation of hypereosinophilic syndrome.
Full Definition
Löffler endocarditis represents the cardiac manifestation of hypereosinophilic syndrome, characterized by eosinophil-mediated endocardial damage leading to thrombosis and progressive fibrosis. The condition progresses through three stages: acute necrotic (eosinophilic infiltration and myocyte damage), thrombotic (mural thrombus formation), and fibrotic (endocardial scarring and restriction). The fibrotic stage leads to obliteration of the cardiac apex and posterior mitral leaflet immobilization. Pathologically, there is dense eosinophilic infiltrate, endocardial thickening, and organized thrombus. The condition most commonly affects tropical regions and is associated with parasitic infections, though it can occur in temperate climates with other causes of hypereosinophilia.
Usage
Usage note: Eponymous term; represents hypereosinophilic syndrome cardiac involvement; distinguish from idiopathic endomyocardial fibrosis.
In Context
- "The echocardiogram showed classic features of Löffler endocarditis with apical obliteration and mitral regurgitation." — Cardiology report
- "Pathological examination revealed the fibrotic stage of Löffler endocarditis with dense endocardial scarring." — Surgical pathology report