antiplatelet therapy
Medications that inhibit platelet aggregation to prevent thrombotic cardiovascular events.
Full Definition
Antiplatelet therapy involves medications that inhibit platelet function and aggregation, thereby reducing the risk of arterial thrombosis and subsequent cardiovascular events. The most common antiplatelet agent is aspirin, which irreversibly inhibits cyclooxygenase-1 and reduces thromboxane A2 production. Other agents include clopidogrel, prasugrel, and ticagrelor, which block the P2Y12 adenosine diphosphate receptor. Antiplatelet therapy is fundamental in both primary and secondary cardiovascular prevention, with aspirin being the cornerstone agent. Dual antiplatelet therapy (DAPT) is typically used following acute coronary syndromes or percutaneous coronary intervention.
Usage
Usage note: Distinguish clearly from anticoagulation therapy. Specify single vs dual therapy.
In Context
- "Lifelong antiplatelet therapy with aspirin was recommended for secondary prevention." — Discharge planning
- "Dual antiplatelet therapy was continued for 12 months post-stenting." — Follow-up protocol