apolipoprotein B
Pronunciation: ap-oh-LIP-oh-proh-teen
Protein component of atherogenic lipoproteins, emerging as superior cardiovascular risk marker compared to LDL cholesterol.
Full Definition
The primary protein component of low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein particles, with each atherogenic particle containing exactly one apolipoprotein B molecule. Measurement of apolipoprotein B (often abbreviated apoB) provides a direct count of atherogenic particles and may be superior to LDL cholesterol for cardiovascular risk assessment, particularly in patients with diabetes, metabolic syndrome, or discordant lipid profiles. Some guidelines now include apoB targets for high-risk patients.
Usage
Usage note: May be abbreviated as apoB; represents particle number rather than cholesterol content.
In Context
- "Apolipoprotein B levels remained elevated despite achieving LDL cholesterol targets." — Lipid management note
- "The apoB/apoA-I ratio provides enhanced cardiovascular risk stratification." — Research finding