ASCOT study
Also written as: ASCOT — Anglo-Scandinavian Cardiac Outcomes Trial
Landmark Anglo-Scandinavian Cardiac Outcomes Trial comparing blood pressure and lipid-lowering strategies.
Full Definition
The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) was a major randomized controlled trial that demonstrated the cardiovascular benefits of amlodipine-based blood pressure treatment and atorvastatin therapy. The study significantly influenced modern cardiovascular prevention guidelines by showing superior outcomes with newer antihypertensive regimens compared to traditional beta-blocker and diuretic combinations. ASCOT's findings regarding statin therapy in patients with normal cholesterol levels helped establish the role of statins in primary prevention.
Usage
Usage note: Often abbreviated in clinical literature; distinguish from ASCVD terminology.
In Context
- "The ASCOT study demonstrated that amlodipine-based treatment was superior to atenolol-based treatment for reducing cardiovascular events." — Clinical research manuscript
- "Guidelines frequently cite ASCOT findings when recommending calcium channel blockers over beta-blockers as first-line therapy." — Treatment guideline document