lipid triad
The combination of low HDL cholesterol, elevated triglycerides, and small dense LDL particles that characterizes atherogenic dyslipidemia.
Full Definition
The lipid triad refers to the characteristic pattern of atherogenic dyslipidemia consisting of low HDL cholesterol (typically <40 mg/dL in men, <50 mg/dL in women), elevated triglycerides (≥150 mg/dL), and predominance of small, dense LDL particles. This lipid pattern is commonly associated with insulin resistance, metabolic syndrome, and type 2 diabetes, and confers increased cardiovascular risk independent of LDL cholesterol levels. The lipid triad often requires targeted therapy beyond standard statin treatment.
Usage
Usage note: Use 'triad' rather than 'trio' in medical contexts; emphasize the interconnected nature of these three lipid abnormalities.
In Context
- "The patient exhibited the classic lipid triad with HDL 35 mg/dL, triglycerides 280 mg/dL, and predominantly small LDL particles." — Lipid specialty consultation
- "Targeting the lipid triad required combination therapy with statin, fibrate, and lifestyle modification." — Treatment plan documentation